Please be aware that when changing the Serial Cache Size as mentioned in Knowledge base
How to configure Simplify 3D for better connection to the PC
Modified on: Tue, 18 Aug, 2015 at 12:26 PM
You also need to disable the auto updating of the profile's attached firmware settings by unchecking the update firmware configuration box in the G-Code tab.
Otherwise the settings will default back to original!
Dear Wcubitt ,
That is correct, however with the new software update ( the 1.4.5 version ) and the new firmware ( the 2.3 version) you no longer have to increase the serial cache size in Simplify 3D for a stable connection .
You can find the steps on how to install the updates in the links below: